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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

BiochemistryMedicineNatural SciencesRational Drug DesignPeptide TherapeuticCyclic Sulfoxide HydroxyethylaminesProtein MisfoldingChemical BiologyPharmacologyVivo ReductionDrug DiscoveryAmyloid β-Peptides