Rainer Machauer

The <scp>BACE</scp> ‐1 inhibitor <scp>CNP</scp> 520 for prevention trials in Alzheimer's disease

Ulf Neumann, Mike Ufer, Laura H. Jacobson et al. · EMBO Molecular Medicine · 2018 · 167 citations · Full text

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

Ulf Neumann, Heinrich Rueeger, Rainer Machauer et al. · Molecular Neurodegeneration · 2015 · 109 citations · Full text

Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides

Heinrich Rueeger, Rainer Lueoend, Olivier Rogel et al. · Journal of Medicinal Chemistry · 2012 · 98 citations · Full text

Pharmaceutical Science, Core Scaffold Selection, Peptide Science +23

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS^G12C for the Treatment of Solid Tumors

Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer et al. · Journal of Medicinal Chemistry · 2022 · 84 citations · Full text

Enantioselective synthesis of (+)-anatoxin-a via enyne metathesis

Jehrod Brenneman, Rainer Machauer, Stephen F. Martin · Tetrahedron · 2004 · 73 citations

Asymmetric Catalysis, Enantioselective Synthesis, Enyne Metathesis +1