Engineering tumors with 3D scaffolds

Claudia Fischbach, Ruth Chen, Takuya Matsumoto, +4

Nature Methods

Tissue EngineeringScaffoldsEngineeringBiomaterials DesignBiofabrication +5

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, +41

Science

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Claudia Stein, Anaïs F. Bardet, Guglielmo Roma, +8

PLoS Genetics

Hippo Pathway ComponentsMolecular RegulationGeneticsCancer BiologyTumor Biology +20

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Diana M. Muñoz, Pamela J. Cassiani, Li Li, +23

Cancer Discovery

Activation of the RAS/Cyclic AMP Pathway Suppresses a TOR Deficiency in Yeast

Tobias Schmelzle, Thomas W. Beck, Dietmar E. Martin, +1

Molecular and Cellular Biology

Ras/cyclic AmpMolecular RegulationSignaling PathwaysMolecular BiologyCellular Physiology +18

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Patricia Marti, Claudia Stein, Tanja Blumer, +17

Hepatology

TIP41 Interacts with TAP42 and Negatively Regulates the TOR Signaling Pathway

Estela Jacinto, Bing Guo, Kim Arndt, +2

Molecular Cell

Protein FunctionSignal TransductionMolecular RegulationTor Signaling PathwayNatural Sciences +5

BIM Regulates Apoptosis during Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms

Arnaud Mailleux, Michael Overholtzer, Tobias Schmelzle, +3

Developmental Cell

Developmental BiologyCell RegulationCell SignalingMedicineApoptosis +10

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

Tobias Schmelzle, Arnaud Mailleux, Michael Overholtzer, +5

Proceedings of the National Academy of Sciences

ApoptosisCell DeathFunctional RoleMammary Gland DevelopmentTumor Biology +14