Lawrence R. Dick

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Proteasome Block, Biochemistry, Mhc Class +13

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Novel Therapy, Medicine, New Approach +9

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Julian Adams, Mark L. Behnke, Shaowu Chen et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 680 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +8

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 457 citations · Full text

Protein Chemistry, Nedd8-amp Mimetic, Protein Function +7

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 414 citations

Medicine, Anti-cancer Agent, Small-molecule Inhibitor +8