Macarena Ortíz

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB

Paola Illesca, Rodrigo Valenzuela, Alejandra Espinosa et al. · Biomedicine & Pharmacotherapy · 2018 · 143 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation

Rodrigo Valenzuela, Paola Illesca, Francisca Echeverría et al. · Food & Function · 2017 · 132 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration

Macarena Ortíz, Sandra Soto-Alarcón, Paula Orellana et al. · Digestive and Liver Disease · 2020 · 129 citations

Life Sciences, Biochemistry, Nutritional Sciences +12

Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2

Francisca Echeverría, Rodrigo Valenzuela, Alejandra Espinosa et al. · The Journal of Nutritional Biochemistry · 2018 · 105 citations · Full text

Life Sciences, Nutrition, Nutritional Sciences +14

Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

Rodrigo Valenzuela, Francisca Echeverría, Macarena Ortíz et al. · Lipids in Health and Disease · 2017 · 104 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17