In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, +16

Nature

Identifies Ptpn2Vivo CrisprImmunologyGene EditingGenome Editing +6

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

Vikram R. Juneja, Kathleen A. McGuire, Robert T. Manguso, +5

The Journal of Experimental Medicine

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, +19

Cell

ObesityCancer ImmunosurveillanceImmunologyTumor ImmunityBiological Microenvironments +6

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

Sonja Kleffel, Christian Posch, Steven R. Barthel, +19

Cell

Cancer ImmunosurveillanceMelanomaMedicineCell BiologyTumor Microenvironment +1

Response to BRAF Inhibition in Melanoma Is Enhanced When Combined with Immune Checkpoint Blockade

Zachary A. Cooper, Vikram R. Juneja, Peter T. Sage, +12

Cancer Immunology Research

ImmunologyImmune RegulationImmunoeditingMelanoma Is EnhancedCd4 T Cell Responses +22

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan, Juhi R. Kuchroo, Peter T. Sage, +15

The Journal of Experimental Medicine

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

Peter T. Sage, Noga Ron‐Harel, Vikram R. Juneja, +8

Nature Immunology

InflammationSelective InhibitionSignal TransductionCell RegulationT-regulatory Cell +12

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Alison M. Paterson, Scott B. Lovitch, Peter T. Sage, +9

The Journal of Experimental Medicine

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, +11

Cancer Immunology Research

Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticle Loaded Poly(lactide-co-glycolide) Microparticles

Chenjie Xu, David Miranda-Nieves, James A. Ankrum, +11

Nano Letters

Tissue EngineeringNanoparticlesNanotherapeuticsEngineeringIron Oxide Nanoparticles +24