Kunihiro Hattori

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei et al. · Nature Medicine · 2012 · 489 citations

Inflammation, Immunohematology, X Restores +10

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa, Shinya Ishii, Tatsuhiko Tachibana et al. · Nature Biotechnology · 2010 · 339 citations

Engineering, Medicine, Immunoengineering +12

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda et al. · PLoS ONE · 2013 · 313 citations · Full text

Immunocytochemical Technique, Immunology, Pathology +23

Reduced elimination of IgG antibodies by engineering the variable region

Tomoyuki Igawa, Hiroyuki Tsunoda, Tatsuhiko Tachibana et al. · Protein Engineering Design and Selection · 2010 · 256 citations

Immunocytochemical Technique, Immunology, Immunodominance +16

An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

Takahiro Ishiguro, Yuji Sano, Shunichiro Komatsu et al. · Science Translational Medicine · 2017 · 195 citations