Tetsuhiro Soeda

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei et al. · Nature Medicine · 2012 · 496 citations

Medicine, Hematology, Immunology +17

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda et al. · PLoS ONE · 2013 · 325 citations · Full text

Pharmacy, Biotechnology, Medicinal Chemistry +17

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

Takehisa Kitazawa, Keiko Esaki, Tatsuhiko Tachibana et al. · Thrombosis and Haemostasis · 2017 · 201 citations · Full text

Pharmacy, Immunology, Molecular Biology +16

Anti‐factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation

A. Muto, Kazutaka Yoshihashi, Minako Takeda et al. · Journal of Thrombosis and Haemostasis · 2013 · 142 citations

Medicine, Hematology, Immunology +17

Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti‐factor IXa/factor X bispecific antibody emicizumab

Keiji Nogami, Tomoko Matsumoto, Yuka Tabuchi et al. · Journal of Thrombosis and Haemostasis · 2018 · 122 citations

Medicine, Hematology, Immunology +14