Hiroyuki Tsunoda

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei et al. · Nature Medicine · 2012 · 496 citations

Medicine, Hematology, Immunology +17

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases

Mineto Ota, Yasuo Nagafuchi, Hiroaki Hatano et al. · Cell · 2021 · 347 citations

Life Sciences, Genetics, Immunology +16

Identification of Soluble NH2-Terminal Fragment of Glypican-3 as a Serological Marker for Early-Stage Hepatocellular Carcinoma

Yoshitaka Hippo, Kiyotaka Watanabe, Akira Watanabe et al. · Cancer Research · 2004 · 297 citations · Full text

Medicine, Molecular Biology, Oncology +17

Reduced elimination of IgG antibodies by engineering the variable region

Tomoyuki Igawa, Hiroyuki Tsunoda, Tatsuhiko Tachibana et al. · Protein Engineering Design and Selection · 2010 · 262 citations

Pharmacy, Immunology, Pharmacokinetics +17

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

Takehisa Kitazawa, Keiko Esaki, Tatsuhiko Tachibana et al. · Thrombosis and Haemostasis · 2017 · 201 citations · Full text

Pharmacy, Immunology, Molecular Biology +16