Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Interleukin‐6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease‐modifying antirheumatic drugs: The tocilizumab in combination with traditional disease‐modifying antirheumatic drug therapy study

Mark C. Genovese, James D. McKay, Eduardo Mysler et al. · Arthritis & Rheumatism · 2008 · 858 citations

Medicine, Pharmacology, Pharmacotherapy +16

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton et al. · Nature Biotechnology · 2010 · 644 citations · Full text

Pharmacy, Immunology, Pharmacokinetics +12

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall’Acqua, Peter A. Kiener, Herren Wu · Journal of Biological Chemistry · 2006 · 637 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

Hisao Hirota, Kiyoshi Yoshida, T. Kishimoto et al. · Proceedings of the National Academy of Sciences · 1995 · 505 citations

Life Sciences, Cardiology, Physiology +17

Crystal structure of the complex of rat neonatal Fc receptor with Fc

Andrew H. Huber, Pamela J. Björkman · Nature · 1994 · 432 citations

Life Sciences, Biochemistry, Molecular Biology +14