Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa, Shinya Ishii, Tatsuhiko Tachibana, +18

Nature Biotechnology

EngineeringMedicineImmunoengineeringImmunologyImmunodominance +10

Induction of Osteogenic Differentiation by Hedgehog Proteins

Takashi Nakamura, Tomonao Aikawa, Motomi Iwamoto-Enomoto, +8

Biochemical and Biophysical Research Communications

Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, Control of Proliferation, and Hypertrophy in Chondrocytes

Motomi Enomoto‐Iwamoto, Masahiro Iwamoto, Yoshiki Mukudai, +7

The Journal of Cell Biology

Alfacalcidol Inhibits Bone Resorption and Stimulates Formation in an Ovariectomized Rat Model of Osteoporosis: Distinct Actions from Estrogen

Ayako Shiraishi, Satoshi Takeda, Toshimi Masaki, +8

Journal of Bone and Mineral Research

MechanobiologyDistinct ActionsBone ResorptionAlfacalcidol IncreasesMedicine +13

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, +11

PLoS ONE

Immunocytochemical TechniqueEngineeringImmunoengineeringImmunologyConventional Antibody +12

Hedgehog Proteins Stimulate Chondrogenic Cell Differentiation and Cartilage Formation

Motomi Enomoto‐Iwamoto, Takashi Nakamura, Tomonao Aikawa, +10

Journal of Bone and Mineral Research

Regenerative MedicineDevelopmental BiologyBone Morphogenic ProteinCartilage FormationIndian Hedgehog +11

IL-6 plays an essential role in neutrophilia under inflammation

Misato Hashizume, Yoshinobu Higuchi, Yasushi Uchiyama, +1

Cytokine

InflammationAutoimmune DiseaseEssential RoleGranulocyteImmunology +4

Transcription Factor Erg Variants and Functional Diversification of Chondrocytes during Limb Long Bone Development

Masahiro Iwamoto, Yoshinobu Higuchi, Eiki Koyama, +6

The Journal of Cell Biology

Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment

Akie Homma, Haruhiko Sato, Akira Okamachi, +21

Bioorganic & Medicinal Chemistry

Regenerative MedicineRheumatologyMedicineOsteoarthritisPharmacology +3

Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, +4

Arthritis Research & Therapy