Kenta Haraya

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei et al. · Nature Medicine · 2012 · 489 citations

Inflammation, Immunohematology, X Restores +10

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa, Shinya Ishii, Tatsuhiko Tachibana et al. · Nature Biotechnology · 2010 · 339 citations

Engineering, Medicine, Immunoengineering +12

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda et al. · PLoS ONE · 2013 · 313 citations · Full text

Immunocytochemical Technique, Immunology, Pathology +23

Anti‐factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation

A. Muto, Kazutaka Yoshihashi, Minako Takeda et al. · Journal of Thrombosis and Haemostasis · 2013 · 138 citations

Inflammation, Thrombosis, Immunohematology +11

Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIaR131 and FcγRIIaH131

Futa Mimoto, Hitoshi Katada, Shojiro Kadono et al. · Protein Engineering Design and Selection · 2013 · 127 citations · Full text