Christopher Towler

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

Impact of Molecular Speciation on Crystal Nucleation in Polymorphic Systems:  The Conundrum of γ Glycine and Molecular ‘Self Poisoning'

Christopher Towler, Roger J. Davey, Robert W. Lancaster et al. · Journal of the American Chemical Society · 2004 · 194 citations

Crystallization in Polymorphic Systems:  The Solution-Mediated Transformation of β to α Glycine

Elena Ferrari, Roger J. Davey, W.I. Cross et al. · Crystal Growth & Design · 2002 · 159 citations

Polymorphic Systems, Crystal Structure, Engineering +16

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16