Atwood K. Cheung

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

Tankyrase Inhibition, Signal Transduction, Signaling Pathway +7

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

James Palacino, Susanne E. Swalley, Cheng Song et al. · Nature Chemical Biology · 2015 · 422 citations

Transcriptional Regulation, Genetics, Gene Regulation +7

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Xinming Cai, YongYao Xu, Atwood K. Cheung et al. · Chemistry & Biology · 2013 · 219 citations · Full text

Inflammation, Cytokine, Signal Transduction +8

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

Michael D. Shultz, Atwood K. Cheung, C.A. Kirby et al. · Journal of Medicinal Chemistry · 2013 · 122 citations · Full text

Drug Target, Selective Tankyrase Inhibitors, Pharmacotherapy +18