Concepedia

Brian Hurley

BH

Statistics

Publications

3

Citations

226

H-Index

3

Active since

2008

Affiliations

Novartis (Switzerland)(Current)

Brian Hurley is an author at Novartis (Switzerland) specializing in medicine, natural sciences, and chemical biology.

Top concepts

MedicineNatural SciencesGeneticsBiochemistryCell BiologyCytoskeletonPharmacologyDrug DiscoveryGene ExpressionChemical Biology

Publications per year

2008–2021

3

Publications

3

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16

Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

Stefan Peukert, Yingchuan Sun, Rui Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 83 citations · Full text

Biochemistry, Undecaprenyl Pyrophosphate Synthase, Natural Sciences +9

Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of <i>N</i>-Methyl-5-aryl-<i>N</i>-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators

Jake Axford, Moo Je Sung, John I. Manchester et al. · Journal of Medicinal Chemistry · 2021 · 15 citations

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