Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey, +24

Science Translational Medicine

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang, +25

ACS Medicinal Chemistry Letters

Selective Smoothened AntagonistChemoprevention StrategyNovel TherapyFunctional SelectivityMedicine +12

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer

George S. Tria, Tinya J. Abrams, Jason R. Baird, +21

Journal of Medicinal Chemistry

Oral BioavailabilityBreast OncologyChemoprevention StrategyPharmacotherapyMolecular Pharmacology +14

1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity

Karen Miller‐Moslin, Stefan Peukert, Rishi K. Jain, +24

Journal of Medicinal Chemistry

Pharmaceutical ScienceAntitumor ActivityPharmacotherapyPharmaceutical ChemistryTumor Biology +14

Molecular Basis for Kv1.5 Channel Block

Niels Decher, Bernard Pirard, Florian Bundis, +5

Journal of Biological Chemistry

Cardiac MuscleKv1.5 ChannelsMolecular BiologyKv1.5 Potassium ChannelsCellular Physiology +17

Discovery of NVP‐LEQ506, a Second‐Generation Inhibitor of Smoothened

Stefan Peukert, Feng He, Miao Dai, +20

ChemMedChem

Molecular PharmacologyContinued OptimizationCompetitor CompoundOncologyFirst Disclosure +13

Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

Stefan Peukert, Yingchuan Sun, Rui Zhang, +8

Bioorganic & Medicinal Chemistry Letters

BiochemistryUndecaprenyl Pyrophosphate SynthaseNatural SciencesMedicineSelective Inhibitors +7

A New Platform for Designing Ligands for Asymmetric Induction in Allylic Alkylations

Barry M. Trost, Bernhard Breit, Stefan Peukert, +2

Angewandte Chemie International Edition in English

Asymmetric InductionCross-coupling ReactionEngineeringAlkene MetathesisNatural Sciences +13

Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(salen) Complexes

Stefan Peukert, Eric N. Jacobsen

Organic Letters

Asymmetric CatalysisDiversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis +11

Electrophysiological and antiarrhythmic effects of the novel I Kur channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I Kr blockers dofetilide, azimilide, d,l-sotalol and ibutilide

Karsten Knobloch, Joachim Brendel, Stefan Peukert, +3

Naunyn-Schmiedeberg s Archives of Pharmacology

Cardiovascular DiseaseMedicinePhysiologyAntiarrhythmic EffectsCardiovascular Pharmacology +7