Jake Axford

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

Thomas A. Hunt, Hazel C. Atherton-Watson, Jake Axford et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 28 citations · Full text

Combinatorial Chemistry, Quaternary Amines, Medicinal Chemistry +12

Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase

Klemens Hoegenauer, Shaojian An, Jake Axford et al. · ACS Medicinal Chemistry Letters · 2023 · 28 citations · Full text

Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of <i>N</i>-Methyl-5-aryl-<i>N</i>-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators

Jake Axford, Moo Je Sung, John I. Manchester et al. · Journal of Medicinal Chemistry · 2021 · 15 citations