Jason T. Lowe

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Lisa A. Marcaurelle, Eamon Comer, Sivaraman Dandapani et al. · Journal of the American Chemical Society · 2010 · 213 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Teng Teng, Jennifer Tsai, Xiaoling Puyang et al. · Nature Communications · 2017 · 149 citations · Full text

Life Sciences, Biology, Molecular Biology +16

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Jason T. Lowe, Maurice D. Lee, Lakshmi B. Akella et al. · The Journal of Organic Chemistry · 2012 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Total Synthesis and Stereochemical Reassignment of (+)‐Neopeltolide

Willmen Youngsaye, Jason T. Lowe, Frauke Pohlki et al. · Angewandte Chemie International Edition · 2007 · 106 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth

Iwona Wrona, Jason T. Lowe, Thomas J. Turbyville et al. · The Journal of Organic Chemistry · 2009 · 65 citations

Pharmacy, Medicinal Chemistry, Oncology +13