Total Synthesis and Stereochemical Reassignment of (+)‐Neopeltolide

Abstract

Take a closer look! The first enantioselective total synthesis, stereochemical reassignment, and absolute configuration of the metabolite neopeltolide is described (see picture). Synthetic highlights of this route include a modified Evans–Tishchenko reduction to introduce the C11 stereocenter, [4+2] annulation to construct the pyran system, and a Still–Gennari olefination to install the oxazole side chain. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z704122_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.