Lakshmi B. Akella

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Lisa A. Marcaurelle, Eamon Comer, Sivaraman Dandapani et al. · Journal of the American Chemical Society · 2010 · 213 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

Felix Kopp, Christopher F. Stratton, Lakshmi B. Akella et al. · Nature Chemical Biology · 2012 · 154 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +14

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Jason T. Lowe, Maurice D. Lee, Lakshmi B. Akella et al. · The Journal of Organic Chemistry · 2012 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

Baudouin Gerard, Morgan Welzel O’Shea, Etienne J. Donckèle et al. · ACS Combinatorial Science · 2012 · 53 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via S_NAr Cycloetherification

Baudouin Gerard, Jeremy R. Duvall, Jason T. Lowe et al. · ACS Combinatorial Science · 2011 · 45 citations

Pharmacy, Chemistry, Medicinal Chemistry +17