Teresa Gmaschitz

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

William Farnaby, Manfred Koegl, Michael J. Roy et al. · Nature Chemical Biology · 2019 · 576 citations · Full text

Life Sciences, Bioinformatics, Oncology +9

Drugging an undruggable pocket on KRAS

Dirk Kessler, Michael Gmachl, Andreas Mantoulidis et al. · Proceedings of the National Academy of Sciences · 2019 · 434 citations · Full text

Medicine, Molecular Biology, Oncology +15

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci et al. · Journal of Medicinal Chemistry · 2018 · 333 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

Nina Kerres, Steffen Steurer, Stefanie Schlager et al. · Cell Reports · 2017 · 206 citations · Full text

Medicine, Cancer Biology, Molecular Biology +11

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Johannes Popow, Heribert Arnhof, Gerd Bader et al. · Journal of Medicinal Chemistry · 2019 · 142 citations · Full text

Life Sciences, Molecular Biology, Oncology +13