Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Dong-Sung Kim, Lorenz Herdeis, Dorothea Rudolph, +21

Nature

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Matthias Muhar, Anja Ebert, Tobias Neumann, +17

Science

GeneticsMolecular BiologyGene Regulatory NetworkDirect TargetsRegulatory Pathways +14

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

Johannes Popow, Markus Englert, Stefan Weitzer, +8

Science

GeneticsRna SplicingMolecular BiologyMolecular GeneticsProtein Genetics +15

The mammalian tRNA ligase complex mediates splicing of <i>XBP1</i> mRNA and controls antibody secretion in plasma cells

Jennifer Jurkin, Theresa Henkel, A. Nielsen, +7

The EMBO Journal

A transcription factor–based mechanism for mouse heterochromatin formation

Aydan Bulut-Karslıoğlu, Valentina Perrera, Manuela Scaranaro, +12

Nature Structural & Molecular Biology

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingNatural Sciences +9

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Johannes Popow, Heribert Arnhof, Gerd Bader, +21

Journal of Medicinal Chemistry

Targeting cancer with small-molecule pan-KRAS degraders

Johannes Popow, William Farnaby, Andreas Gollner, +40

Science

Tumor BiologyGenetic Kras AberrationsOncogenic KrasEngineeringOncogenic Agent +13

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Johannes Popow, Jennifer Jurkin, Alexander Schleiffer, +1

Nature

BiologyNatural SciencesGeneticsRna Structure PredictionGene Structure +8

FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation

Johannes Popow, Anne-Marie Alleaume, Tomaž Curk, +3

RNA

Mitochondrial Rna BiogenesisMitophagySystems BiologyEngineeringMitochondrial Biogenesis +9

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

Daniel Gerlach, Ulrike Tontsch-Grunt, Anke Baum, +11

Oncogene