Ida Giardino

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Takeshi Nishikawa, Diane Edelstein, Xue Du et al. · Nature · 2000 · 4.2K citations

Metabolic Syndrome, Biochemistry, Mitochondrial Function +11

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Hans-Peter Hammes, Xueliang Du, Diane Edelstein et al. · Nature Medicine · 2003 · 777 citations

Metabolic Syndrome, Diabetic Retinopathy, Ocular Disease +12

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Masahiro Shinohara, Paul J. Thornalley, Ida Giardino et al. · Journal of Clinical Investigation · 1998 · 510 citations · Full text

Lipid Peroxidation, Glycobiology, Metabolic Remodeling +24

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

Alessandro Luciani, Valeria Rachela Villella, Speranza Esposito et al. · Nature Cell Biology · 2010 · 452 citations

Inflammation, Cell Autophagy, Mitophagy +11

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

Ida Giardino, Diane Edelstein, Michael Brownlee · Journal of Clinical Investigation · 1994 · 362 citations · Full text