Speranza Esposito

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

Alessandro Luciani, Valeria Rachela Villella, Speranza Esposito et al. · Nature Cell Biology · 2010 · 452 citations

Inflammation, Cell Autophagy, Mitophagy +11

Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect

Valeria Rachela Villella, Speranza Esposito, Emanuela M. Bruscia et al. · Frontiers in Pharmacology · 2013 · 388 citations · Full text

Cell Autophagy, Mitophagy, Fibrosis +15

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

Daniela De Stefano, Valeria Rachela Villella, Speranza Esposito et al. · Autophagy · 2014 · 142 citations · Full text

Human Cystic Fibrosis, Inflammatory Lung Disease, Lung Inflammation +16

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

Antonella Tosco, Fabiola De Gregorio, Speranza Esposito et al. · Cell Death and Differentiation · 2016 · 91 citations · Full text

Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

Alessandro Luciani, Valeria Rachela Villella, Speranza Esposito et al. · Autophagy · 2012 · 90 citations · Full text

Mitophagy, Therapeutic Action, Inflammatory Lung Disease +26