Thekla S. Diehl

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +8

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

Dean M. Hartley, Dominic M. Walsh, C P Ye et al. · PubMed · 1999 · 921 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

Dean M. Hartley, Dominic M. Walsh, Chianping P. Ye et al. · Journal of Neuroscience · 1999 · 812 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 520 citations

Life Sciences, Biochemistry, Medicinal Chemistry +13