Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca²⁺Channel Antagonist

William D. Shipe, James C. Barrow, Zhi-Qiang Yang, +27

Journal of Medicinal Chemistry

Medicinal ChemistrySelective AntagonistMedicineDrug DiscoveryPhysiology +10

Pharmacokinetics of Dietary Phenethyl Isothiocyanate in Rats

Yan Ji, Yuhsin Kuo, Marilyn E. Morris

Pharmaceutical Research

Pharmacokinetic ModelingPharmacological StudyMedicinePhysiologyToxicology +4

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

Zhiqiang Yang, James C. Barrow, William D. Shipe, +29

Journal of Medicinal Chemistry

1,4-Substituted PiperidinesSelective InhibitorsPharmacotherapyLimited SelectivityMedicinal Chemistry +17

In Vitro Assessment of Drug-Drug Interaction Potential of Boceprevir Associated with Drug Metabolizing Enzymes and Transporters

Xiaoyan Chu, Xiaoxin Cai, Donghui Cui, +10

Drug Metabolism and Disposition

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Edward J. Brnardic, Mark E. Fraley, R. M. Garbaccio, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPsychoactive DrugPsychiatryPositive Allosteric ModulatorsPharmacology +9

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists

James C. Barrow, Kenneth E. Rittle, Thomas S. Reger, +19

ACS Medicinal Chemistry Letters

NeurotransmitterPharmacotherapySocial Sciences4,4-Disubstituted Quinazolin-2-onesRat Active Wake +15

In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies

Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, +7

Drug Metabolism and Disposition

Pyridyl amides as potent inhibitors of T-type calcium channels

Thomas S. Reger, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentT-type Calcium ChannelsPharmacotherapy +3

Bioactivation of 2,3-Diaminopyridine-Containing Bradykinin B₁ Receptor Antagonists:  Irreversible Binding to Liver Microsomal Proteins and Formation of Glutathione Conjugates

Cuyue Tang, Raju Subramanian, Yuhsin Kuo, +10

Chemical Research in Toxicology

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Kelly-Ann S. Schlegel, Zhi-Qiang Yang, Thomas S. Reger, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNatural SciencesIon ChannelsChemical Biology +5