William D. Shipe

Selective activation of the M ₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Lei Ma, Matthew A. Seager, Marion Wittmann et al. · Proceedings of the National Academy of Sciences · 2009 · 282 citations · Full text

Synaptic Transmission, Neurotransmitter, Selective Activation +21

Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca²⁺Channel Antagonist

William D. Shipe, James C. Barrow, Zhi-Qiang Yang et al. · Journal of Medicinal Chemistry · 2008 · 131 citations · Full text

Medicinal Chemistry, Selective Antagonist, Medicine +12

Convergent, Enantioselective Syntheses of Guanacastepenes A and E Featuring a Selective Cyclobutane Fragmentation¹

William D. Shipe, Erik J. Sorensen · Journal of the American Chemical Society · 2006 · 110 citations

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

Zhiqiang Yang, James C. Barrow, William D. Shipe et al. · Journal of Medicinal Chemistry · 2008 · 92 citations · Full text

1,4-Substituted Piperidines, Selective Inhibitors, Pharmacotherapy +19

A Convergent Synthesis of the Tricyclic Architecture of the Guanacastepenes Featuring a Selective Ring Fragmentation

William D. Shipe, Erik J. Sorensen · Organic Letters · 2002 · 68 citations