Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S -methyltransferase

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

Lynne Lennard, J S Lilleyman, Jon Van Loon et al. · The Lancet · 1990 · 659 citations

Hematological Malignancy, Pediatric Hematology, Mixed-phenotype Acute Leukemia +7

Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties

Richard M. Weinshilboum, F.A. Raymond, P.A. Pazmiño · Clinica Chimica Acta · 1978 · 346 citations

Biochemistry, Bioanalysis, Toxicology +3

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.

Eugene Y. Krynetski, Natalia F. Krynetskaia, Yuri Yanishevski et al. · Molecular Pharmacology · 1995 · 118 citations

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?

Lynne Lennard, HA Davies, J S Lilleyman · British Journal of Cancer · 1993 · 100 citations · Full text

Hematological Malignancy, Acute Lymphoblastic Leukaemia, Pediatric Hematology +6

Individualizing Therapy with 6-Mercaptopurine and 6-Thioguanine Related to the Thiopurine Methyltransferase Genetic Polymorphism

Lynne Lennard, John Lilleyman · Therapeutic Drug Monitoring · 1996 · 89 citations

Genetics, Human Polymorphism, Molecular Biology +16