Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40)

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Andrew J. Brown, Susan M. Goldsworthy, Ashley Barnes et al. · Journal of Biological Chemistry · 2003 · 2.3K citations · Full text

Medicine, Biochemistry, Pharmacology +17

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Akira Hirasawa, Keiko Tsumaya, Takeo Awaji et al. · Nature Medicine · 2004 · 1.5K citations

Life Sciences, Endocrinology, Molecular Biology +13

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

Life Sciences, Cell Biology, Endocrinology +16

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

QXP: Powerful, rapid computer algorithms for structure-based drug design

Colin McMartin, Regine S. Bohacek · Journal of Computer-Aided Molecular Design · 1997 · 512 citations

Pharmacy, Bioinformatics, Medicinal Chemistry +12