Molecular Therapy · 2024 · 38 citations · 34 references
MedicineImmunologyOncologyCancer ImmunologyImmunotherapyTumor MicroenvironmentAntitumor T Cell ResponsesCancer ImmunotherapyCytotoxic T Lymphocyte ResponsesReactive Oxygen SpeciesT Cell ExhaustionTumor Immune MicroenvironmentCancer-associated ImmunosuppressionImmunosuppressive MicroenvironmentNrf2 Pathway ActivationNrf2 Signaling PathwayNrf2-mediated ResponsesNuclear Factor Erythroid 2-Related Factor 2 SignalingOxidative Stress In CancerReactive Oxygen Species Generation
T cells. Nrf2-deficient CTLs are resistant to ROS, and their effector functions are sustained in the TME. Furthermore, Nrf2 knockdown in human CAR-T cells enhanced the survival and function of intratumoral CAR-T cells in a solid tumor xenograft model and effectively controlled tumor growth. ROS-sensing Nrf2 inhibits the anti-tumor T cell responses, indicating that Nrf2 may be a potential target for T cell immunotherapy strategies against solid tumors.
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan et al. · Science · 2016 · 5.2K citations · Full text
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
E. John Wherry, Sang‐Jun Ha, Susan M. Kaech et al. · Immunity · 2007 · 2.1K citations
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
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Hanjie Li, Anne M. van der Leun, Ido Yofe et al. · Cell · 2018 · 1.1K citations · Full text
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