Concepedia

Nrf2-mediated Responses

Nrf2-Mediated Responses is a molecular signaling mechanism that regulates the cellular antioxidant defense system by activating the transcription of cytoprotective genes in response to oxidative stress and electrophilic agents.

5K

Publications

346.3K

Citations

27.1K

Authors

3.9K

Institutions

Publications per year

2017–2026

2.9K

Parents

Publications

5K

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

, , +14

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

, , +16

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

, , +16

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Ashish Jain, Trond Lamark, Eva Sjøttem et al. · Journal of Biological Chemistry · 2010 · 1.5K citations · Full text

, , +17

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

, , +13

1–5 of 5K

Authors

27.1K

  1. MY
    Masayuki Yamamoto

    Tohoku University, Japan

    165 publications · 36.6K citations

    94

    h-index

  2. KI
    Ken Itoh

    Hirosaki University, Japan

    56 publications · 22.1K citations

    46

    h-index

  3. TW
    Thomas W. Kensler

    Johns Hopkins University, United States

    56 publications · 12.7K citations

    44

    h-index

  4. AT
    Ah‐Ng Tony Kong

    Rutgers, The State University of New Jersey, United States

    48 publications · 4.8K citations

    37

    h-index

  5. SB
    Shyam Biswal

    Johns Hopkins University, United States

    32 publications · 5.2K citations

    28

    h-index

1–5 of 27.1K

Institutions

3.9K

  1. Johns Hopkins University

    Baltimore, United States

    75 h-index

    503 publications

    119K citations

  2. University of Tsukuba

    Tsukuba, Japan

    69 h-index

    488 publications

    168.9K citations

  3. Tohoku University

    Sendai, Japan

    69 h-index

    429 publications

    55.3K citations

  4. Rutgers, The State University of New Jersey

    New Brunswick, United States

    50 h-index

    377 publications

    37.4K citations

  5. Jilin University

    Changchun, China

    48 h-index

    511 publications

    34.3K citations

  6. Johns Hopkins Medicine

    Baltimore, United States

    46 h-index

    204 publications

    35.7K citations

  7. University of Arizona

    Tucson, United States

    42 h-index

    283 publications

    52.9K citations

  8. University of Dundee

    Dundee, United Kingdom

    38 h-index

    168 publications

    27.3K citations

1–8 of 3.9K

Venues

  1. Free Radical Biology and Medicine

    236 publications · 18.1K citations

    77

    h-index

  2. Journal of Biological Chemistry

    JBC · 69 publications · 14.7K citations

    54

    h-index

  3. Redox Biology

    102 publications · 7.6K citations

    51

    h-index

  4. PLoS ONE

    88 publications · 6.2K citations

    50

    h-index

  5. Oxidative Medicine and Cellular Longevity

    124 publications · 6.6K citations

    49

    h-index

1–5