Concepedia

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Matthew Holderfield, Bianca J. Lee, Jingjing Jiang, Aidan C.A. Tomlinson, Kyle J. Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin,

Nature · 2024 · 268 citations · 31 references

DOIFull text

Open access

References

31

Colorectal cancer statistics, 2023

Rebecca L. Siegel, Nikita Sandeep Wagle, Andrea Cercek et al. · CA A Cancer Journal for Clinicians · 2023 · 3.6K citations · Full text

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos et al. · Nature · 2013 · 2.4K citations · Full text

, , +7

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

Keith T. Flaherty, Caroline Robert, Peter Hersey et al. · New England Journal of Medicine · 2012 · 2.1K citations · Full text

Sotorasib for Lung Cancers with <i>KRAS</i> p.G12C Mutation

Ferdinandos Skoulidis, Bob T. Li, Grace K. Dy et al. · New England Journal of Medicine · 2021 · 1.6K citations · Full text

Acquired Resistance to KRAS <sup>G12C</sup> Inhibition in Cancer

New England Journal of Medicine · 2021 · 1.1K citations · Full text