Concepedia

Codon 61 Mutations

Codon 61 Mutations is a molecular oncogenic alteration in the RAS family of genes characterized by specific nucleotide substitutions at the 61st codon position that impair GTPase activity, leading to constitutive RAS activation and sustained downstream signaling in cancer.

487

Publications

40.8K

Citations

2.5K

Authors

653

Institutions

Publications per year

2017–2026

27

Parents

Publications

487

ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

, , +17

A Comprehensive Survey of Ras Mutations in Cancer

Ian A. Prior, Paul D. Lewis, Carla Mattos · Cancer Research · 2012 · 2.1K citations · Full text

, , +17

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Klaus Scheffzek, Mohammad Reza Ahmadian, Wolfgang Kabsch et al. · Science · 1997 · 1.6K citations

, , +17

<i>RAS</i>Point Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma

Marina N. Nikiforova, Roy A. Lynch, Paul W. Biddinger et al. · The Journal of Clinical Endocrinology & Metabolism · 2003 · 713 citations · Full text

, , +17

KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

Fotios Loupakis, Annamaria Ruzzo, Chiara Cremolini et al. · British Journal of Cancer · 2009 · 561 citations · Full text

, , +17

1–5 of 487

Authors

2.5K

  1. TR
    Theodora R. Devereux

    National Institute of Environmental Health Sciences, United States

    10 publications · 362 citations

    10

    h-index

  2. AB
    Albrecht Buchmann

    University of Tübingen, Germany

    9 publications · 567 citations

    9

    h-index

  3. SN
    Susumu Nishimura

    National Cancer Research Institute, United Kingdom

    8 publications · 534 citations

    8

    h-index

  4. RC
    Robert C. Sills

    National Institute of Environmental Health Sciences, United States

    8 publications · 232 citations

    8

    h-index

  5. JL
    Johannes L. Bos

    Utrecht University, Netherlands

    7 publications · 1.7K citations

    7

    h-index

1–5 of 2.5K

Institutions

653

  1. National Institute of Environmental Health Sciences

    Durham, United States

    20 h-index

    77 publications

    4.8K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    16 h-index

    52 publications

    3.5K citations

  3. National Cancer Institute

    Bethesda, United States

    14 h-index

    51 publications

    3K citations

  4. German Cancer Research Center

    Heidelberg, Germany

    13 h-index

    52 publications

    3.7K citations

  5. Heidelberg University

    Heidelberg, Germany

    12 h-index

    58 publications

    3.2K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    11 h-index

    46 publications

    5.7K citations

  7. National Cancer Research Institute

    London, United Kingdom

    11 h-index

    39 publications

    1.8K citations

  8. University of Chicago

    Chicago, United States

    9 h-index

    22 publications

    757 citations

1–8 of 653

Venues

  1. PubMed

    Repository · 89 publications · 12.1K citations

    45

    h-index

  2. Molecular Carcinogenesis

    50 publications · 2.1K citations

    27

    h-index

  3. Carcinogenesis

    43 publications · 1.6K citations

    25

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 3.9K citations

    24

    h-index

  5. International Journal of Cancer

    28 publications · 1.6K citations

    21

    h-index

1–5