Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shikshya Shrestha, Steven M. Offer · Medical Epigenetics · 2016 · 9K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou et al. · Nature · 2002 · 2.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji et al. · Nature · 2012 · 1.8K citations

Medicine, Molecular Genetics, Oncology +15

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Kexin Xu, Zhenhua J. Wu, Anna C. Groner et al. · Science · 2012 · 879 citations · Full text

Medicine, Molecular Biology, Oncology +17

EZH2 Expression Is Associated With High Proliferation Rate and Aggressive Tumor Subgroups in Cutaneous Melanoma and Cancers of the Endometrium, Prostate, and Breast

Ingeborg Bachmann, Ole J. Halvorsen, Karin Collett et al. · Journal of Clinical Oncology · 2005 · 844 citations

Medicine, Genetics, Oncology +17