Concepedia

Ezh2 Function

EZH2 Function is a molecular mechanism within the Polycomb repression system that catalyzes the trimethylation of histone H3 at lysine 27, thereby mediating transcriptional silencing of target genes.

1.1K

Publications

95.5K

Citations

8.8K

Authors

1.7K

Institutions

Publications per year

2017–2026

621

Parents

Publications

1.1K

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou et al. · Nature · 2002 · 2.7K citations · Full text

, , +14

The Polycomb group protein EZH2 directly controls DNA methylation

Emmanuelle Viré, Carmen Brenner, Rachel Deplus et al. · Nature · 2005 · 2.2K citations

, , +14

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji et al. · Nature · 2012 · 1.8K citations

, , +15

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Celina G. Kleer, Qi Cao, Sooryanarayana Varambally et al. · Proceedings of the National Academy of Sciences · 2003 · 1.6K citations · Full text

, , +17

EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer

Adrian P. Bracken · The EMBO Journal · 2003 · 1.2K citations · Full text

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1–5 of 1.1K

Authors

8.8K

  1. HK
    Heike Keilhack

    Epizyme (United States), United States

    12 publications · 3K citations

    12

    h-index

  2. VE
    Víctor E. Márquez

    National Cancer Institute, United States

    13 publications · 2.5K citations

    12

    h-index

  3. JJ
    Jian Jin

    Icahn School of Medicine at Mount Sinai, United States

    11 publications · 905 citations

    11

    h-index

  4. AI
    Atsushi Iwama

    Chiba University, Japan

    11 publications · 1K citations

    11

    h-index

  5. MH
    Mien‐Chie Hung

    The University of Texas MD Anderson Cancer Center, United States

    10 publications · 2.2K citations

    10

    h-index

1–5 of 8.8K

Institutions

1.7K

  1. Sun Yat-sen University

    Guangzhou, China

    32 h-index

    265 publications

    20.1K citations

  2. Harvard University

    Cambridge, United States

    30 h-index

    177 publications

    43.1K citations

  3. University of Michigan

    Ann Arbor, United States

    29 h-index

    194 publications

    65.5K citations

  4. Shanghai Jiao Tong University

    Shanghai, China

    25 h-index

    218 publications

    14.7K citations

  5. Huazhong University of Science and Technology

    Wuhan, China

    24 h-index

    154 publications

    9.2K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    22 h-index

    179 publications

    42.5K citations

  7. Mayo Clinic

    Rochester, United States

    21 h-index

    130 publications

    11.9K citations

  8. Inserm

    Paris, France

    21 h-index

    176 publications

    9K citations

1–8 of 1.7K

Venues

  1. Oncogene

    33 publications · 2.5K citations

    27

    h-index

  2. Oncotarget

    31 publications · 2.1K citations

    25

    h-index

  3. Blood

    28 publications · 4K citations

    22

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 5.8K citations

    22

    h-index

  5. Nature Communications

    24 publications · 2.7K citations

    21

    h-index

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