Kwang‐Su Park

Discovery of a first-in-class EZH2 selective degrader

Anqi Ma, Kwang‐Su Park, Jieli Wei et al. · Nature Chemical Biology · 2019 · 219 citations · Full text

Engineering, Degradation Reaction, Structure Elucidation +3

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Jun Wang, Xufen Yu, Weida Gong et al. · Nature Cell Biology · 2022 · 176 citations · Full text

Chromatin, Transcriptional Regulation, Systems Biology +11

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Xufen Yu, Dongxu Li, Jithesh Kottur et al. · Science Translational Medicine · 2021 · 149 citations · Full text

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Jieli Wei, Fanye Meng, Kwang‐Su Park et al. · Journal of the American Chemical Society · 2021 · 130 citations · Full text

Protein Function, Protein Expression, Keap1 Ligand +12

In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates

Mi Kyoung Kim, Kwang‐Su Park, Woon‐Seok Yeo et al. · Bioorganic & Medicinal Chemistry · 2008 · 128 citations

Vitro Solubility, Biochemistry, Medicine +5