4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation

First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

Osasenaga M. Ighodaro, Oluseyi Adeboye Akinloye · Alexandria Journal of Medicine · 2017 · 3.9K citations · Full text

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

Life Sciences, Biochemistry, Cell Biology +12

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Matthew D. Hirschey, Tadahiro Shimazu, Eric S. Goetzman et al. · Nature · 2010 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

Xiaolei Qiu, Katharine Brown, Matthew D. Hirschey et al. · Cell Metabolism · 2010 · 1.3K citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +14

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi et al. · Proceedings of the National Academy of Sciences · 2013 · 1.2K citations · Full text

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