Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi, +12

Proceedings of the National Academy of Sciences

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state

Semra Smajić, Cesar A. Prada‐Medina, Zied Landoulsi, +16

Brain

Idiopathic ParkinsonEngineeringGeneticsNeurochemical BiomarkersDisease Gene Identification +16

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Johannes Meiser, Lisa Krämer, Sean C. Sapcariu, +5

Journal of Biological Chemistry

InflammationAnti-inflammatoryBiochemistryLipid PeroxidationImmunology +9

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Max Borsche, Inke R. König, Sylvie Delcambre, +19

Brain

MitophagyImmunologyCell DeathPathologyImmune System +17

Simultaneous extraction of proteins and metabolites from cells in culture

Sean C. Sapcariu, Tamara Kanashova, Daniel Weindl, +3

MethodsX

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

Michaël Schnekenburger, Cindy Grandjenette, Jenny Ghelfi, +4

Biochemical Pharmacology

Hematological MalignancyChromatinChronic Myeloid LeukemiaMedicineApoptosis +7

Mutations in <i>RHOT1</i> Disrupt Endoplasmic Reticulum–Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease

Clara Berenguer-Escuder, Marie E. Bellet, David Scheibner, +16

Antioxidants and Redox Signaling

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

Tom Juncker, Claudia Cerella, Marie‐Hélène Teiten, +8

Biochemical Pharmacology

Hematological MalignancyChemoprevention StrategyMedicineMalignant Blood DisorderApoptosis +9

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

Johannes Meiser, Sylvie Delcambre, André Wegner, +20

Neurobiology of Disease

Parkin Deficiency Impairs Mitochondrial <scp>DNA</scp> Dynamics and Propagates Inflammation

Kobi Wasner, Semra Smajić, Jenny Ghelfi, +21

Movement Disorders