SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Matthew D. Hirschey, Tadahiro Shimazu, Eric S. Goetzman, +17

Nature

Mitochondrial FunctionBiochemistryMitochondrial Fatty-acid OxidationMetabolismMedicine +2

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Tadahiro Shimazu, Matthew D. Hirschey, John C. Newman, +13

Science

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

Matthew D. Hirschey, Tadahiro Shimazu, Enxuan Jing, +18

Molecular Cell

Metabolic SyndromeMetabolic DisorderMitochondrial FunctionSirt3 DeficiencyGenetics +8

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

Tadahiro Shimazu, Matthew D. Hirschey, Lan Hua, +9

Cell Metabolism

Mitochondrial FunctionBiochemistryNatural SciencesMitochondrial DynamicGene Expression +6

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, +19

Molecular Cell

ChromatinNatural SciencesGeneticsDna MethylationEpigenetic Change +12

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

Hyun‐Soo Cho, Tadahiro Shimazu, Gouji Toyokawa, +13

Nature Communications

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2

Matthew D. Hirschey, Tadahiro Shimazu, John A. Capra, +2

Aging

ChromatinMitophagySystems BiologyMitochondrial FunctionMolecular Regulation +13

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, +25

Nature Communications

Selenium-Based S-Adenosylmethionine Analog Reveals the Mammalian Seven-Beta-Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase

Tadahiro Shimazu, Joaquin Barjau, Yoshihiro Sohtome, +2

PLoS ONE

Histone ModificationsMolecular RegulationEpigenetic ChangeMolecular BiologyChemical Biology +16

Acetate metabolism and aging: An emerging connection

Tadahiro Shimazu, Matthew D. Hirschey, Jingyi Huang, +2

Mechanisms of Ageing and Development

AgingBiochemistryLongevityPhysiologyAcetate Metabolism +5