The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Life Sciences, Molecular Biology, Oncology +14

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

David Smotkin, F O Wettstein · Proceedings of the National Academy of Sciences · 1986 · 666 citations

Life Sciences, Genetics, Molecular Biology +17

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

William C. Phelps, Carole Yee, Karl Münger et al. · Cell · 1988 · 661 citations

Life Sciences, Genetics, Molecular Biology +16

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

Dharminder Chauhan, Ze Tian, Benjamin Nicholson et al. · Cancer Cell · 2012 · 581 citations

Medicine, Molecular Biology, Oncology +17

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

A.P. Turnbull, Stephanos Ioannidis, Wojciech Krajewski et al. · Nature · 2017 · 468 citations

Medicine, Molecular Biology, Pharmacology +14