Concepedia

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

Dharminder Chauhan, Ze Tian, Benjamin Nicholson, Suresh Kumar, Bin Zhou, Ruben D. Carrasco, Jeffrey L. McDermott, Craig A. Leach, Mariaterresa Fulcinniti, Matthew P. Kodrasov,

Cancer Cell · 2012 · 575 citations · 32 references

DOI

Concepts

References

32

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.1K citations

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Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

Paul G. Richardson, Bart Barlogie, James R. Berenson et al. · New England Journal of Medicine · 2003 · 2.6K citations · Full text

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

Shengyun Fang, Jane P. Jensen, Robert L. Ludwig et al. · Journal of Biological Chemistry · 2000 · 1K citations · Full text

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Muyang Li, Delin Chen, Ariel Shiloh et al. · Nature · 2002 · 1K citations

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