Concepedia

Dual-locus, dual-HDR editing permits efficient generation of antigen-specific regulatory T cells with robust suppressive activity

Martina S. Hunt, Soo Jung Yang, Emma Mortensen, Ahmad Boukhris, Jane H. Buckner, Peter J. Cook, David J. Rawlings

Molecular Therapy · 2023 · 22 citations · 36 references

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References

36

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem, Jorge Mansilla‐Soto, Theodoros Giavridis et al. · Nature · 2017 · 1.8K citations · Full text

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CRISPR-engineered T cells in patients with refractory cancer

Edward A. Stadtmauer, Joseph A. Fraietta, Megan M. Davis et al. · Science · 2020 · 1.4K citations · Full text

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Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

Jiangtao Ren, Xiaojun Liu, Chongyun Fang et al. · Clinical Cancer Research · 2016 · 938 citations

, , +17

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Joseph A. Fraietta, Christopher L. Nobles, Morgan A. Sammons et al. · Nature · 2018 · 861 citations · Full text

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Reprogramming human T cell function and specificity with non-viral genome targeting

Theodore L. Roth, Cristina Puig-Saus, Ruby Yu et al. · Nature · 2018 · 853 citations · Full text

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