Christopher L. Nobles

CRISPR-engineered T cells in patients with refractory cancer

Edward A. Stadtmauer, Joseph A. Fraietta, Megan M. Davis et al. · Science · 2020 · 1.4K citations · Full text

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

J. Joseph Melenhorst, Gregory M. Chen, Meng Wang et al. · Nature · 2022 · 851 citations · Full text

Hematological Malignancy, Decade-long Leukaemia Remissions, Malignant Blood Disorder +8

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Joseph A. Fraietta, Christopher L. Nobles, Morgan A. Sammons et al. · Nature · 2018 · 829 citations · Full text

Cd19-targeted T Cells, Cancer Immunosurveillance, Immunology +8

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Katherine M. Bruner, Zheng Wang, Francesco R. Simonetti et al. · Nature · 2019 · 715 citations · Full text

Viral Persistence, Viral Diagnostics, Human Retrovirus +8

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Marco Ruella, Jun Xu, David M. Barrett et al. · Nature Medicine · 2018 · 620 citations · Full text

Autoimmune Disease, Immunology, Antigen Processing +5