Concepedia

Reprogramming human T cell function and specificity with non-viral genome targeting

Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, Julia Carnevale, P. Jonathan Li, Joseph Hiatt, Justin D. Saco, Paige Krystofinski, Han Li,

Nature · 2018 · 853 citations · 23 references

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23

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

, , +17

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell · 2013 · 3.4K citations · Full text

, , +16

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Kyle Kai-How Farh, Alexander Marson, Jiang Zhu et al. · Nature · 2014 · 2.2K citations · Full text

, , +14

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

Peter J. Skene, Steven Henikoff · eLife · 2017 · 1.9K citations · Full text

, , +11