Reprogramming human T cell function and specificity with non-viral genome targeting

Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, +42

Nature

Immunological MemoryNon-viral Genome TargetingAdaptive Immune SystemT-regulatory CellImmunology +7

McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences

Nili Tickotsky, Tal Sagiv, Jaime Prilusky, +2

Bioinformatics

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

Eric Shifrut, Julia Carnevale, Victoria Tobin, +7

Cell

Immunological MemoryAutoimmune DiseaseAdaptive Immune SystemT-regulatory CellGenome-wide Crispr Screens +9

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Julia A. Belk, Winnie Yao, Nghi Ly, +17

Cancer Cell

ChromatinChromatin RemodelingGeneticsGenome-wide Crispr ScreensGene Editing +7

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

David N. Nguyen, Theodore L. Roth, P. Jonathan Li, +11

Nature Biotechnology

Genome Editing EfficiencyRepair TemplatesEngineeringGenetic EngineeringMolecular Biology +8

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging

Kuti Baruch, Noga Ron‐Harel, Hilah Gal, +12

Proceedings of the National Academy of Sciences

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Jessica T. Cortez, Elena Montauti, Eric Shifrut, +22

Nature

GeneticsT-regulatory CellGene EditingGenome EditingGene Expression +6

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, +20

Nature Biotechnology

Primary CellsGenome InstabilityHigh-yield Genome EngineeringEngineeringSmall-molecule Cocktails +9

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Julia Carnevale, Eric Shifrut, Nupura Kale, +30

Nature

T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity

Asaf Madi, Eric Shifrut, Shlomit Reich-Zeliger, +5

Genome Research

Mhc-diverse Cdr3 SequencesSelf-related ImmunityAdaptive Immune SystemGeneticsT-regulatory Cell +23