Concepedia

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Kyle Kai-How Farh, Alexander Marson, Jiang Zhu, Markus Kleinewietfeld, William Housley, Samantha Beik, Noam Shoresh, Holly Whitton, Russell J.H. Ryan, A.A. Shishkin,

Nature · 2014 · 2.2K citations · 51 references

Open access

Concepts

Life SciencesGeneticsMolecular GeneticsAutoimmunityEpigeneticsEpigenomicsAutoimmune Disease PathogenesisAutoimmune Disease Susceptibility GenesAutoimmune DiseasesAutoimmune PathogenesisGenetic Fine-mappingGenetic Susceptibility To AutoimmunityAutoimmune Disease GeneticsChromatin Accessibility Fine-mappingEpigenetic Qtl MappingGenome-wide Association Study Fine-mappingHeritability Of Autoimmune Disease

References

51

Fast and accurate short read alignment with Burrows–Wheeler transform

Heng Li, Richard Durbin · Bioinformatics · 2009 · 62.8K citations · Full text

Life Sciences, Bioinformatics, Biology +12

Fast gapped-read alignment with Bowtie 2

Ben Langmead, Steven L. Salzberg · Nature Methods · 2012 · 61.1K citations

Life Sciences, Bioinformatics, Molecular Biology +11

An integrated encyclopedia of DNA elements in the human genome

Nature · 2012 · 19.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz, Christopher Benner, Nathanael J. Spann et al. · Molecular Cell · 2010 · 14.6K citations · Full text

Life Sciences, Immunology, Molecular Biology +14

An integrated map of genetic variation from 1,092 human genomes

Nature · 2012 · 8.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17