Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem, Jorge Mansilla‐Soto, Theodoros Giavridis, +6

Nature

Crispr/cas9 Enhances TumourTrac LocusEngineeringOff-target EffectGenetic Engineering +8

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Theodoros Giavridis, Sjoukje J. C. van der Stegen, Justin Eyquem, +3

Nature Medicine

Immune ActivationAdaptive Immune SystemImmunologyImmunologic MechanismCd4 T Cell Responses +15

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Mohamad Hamieh, Anton Dobrin, Annalisa Cabriolu, +14

Nature

Cancer ImmunosurveillanceTumour Antigen EscapeImmunologyRegulatory T CellsAntigen Processing +6

Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

Laurent Poirot, Brian Philip, Cécile Schiffer-Mannioui, +17

Cancer Research

Cell TherapyAdaptive Immune SystemT-regulatory CellImmunologyImmunodominance +18

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Judith Feucht, Jie Sun, Justin Eyquem, +7

Nature Medicine

Signal TransductionAdaptive Immune SystemT-regulatory CellImmunologyAutoimmunity +6

Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML

Fabiana Perna, Samuel Berman, Rajesh Soni, +6

Cancer Cell

Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape

Carl J. DeSelm, M. Lia Palomba, Joachim Yahalom, +4

Molecular Therapy

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, +20

Nature Biotechnology

Primary CellsGenome InstabilityHigh-yield Genome EngineeringEngineeringSmall-molecule Cocktails +9

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Julia Carnevale, Eric Shifrut, Nupura Kale, +30

Nature

HLA-independent T cell receptors for targeting tumors with low antigen density

Jorge Mansilla‐Soto, Justin Eyquem, Sascha Haubner, +22

Nature Medicine

Cancer ImmunosurveillanceT-regulatory CellImmunologyTumor ImmunityAntigen Processing +7