Sjoukje J. C. van der Stegen

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem, Jorge Mansilla‐Soto, Theodoros Giavridis et al. · Nature · 2017 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +12

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Theodoros Giavridis, Sjoukje J. C. van der Stegen, Justin Eyquem et al. · Nature Medicine · 2018 · 1.3K citations · Full text

Life Sciences, Cell Biology, Immunology +16

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

Zeguo Zhao, Maud Condomines, Sjoukje J. C. van der Stegen et al. · Cancer Cell · 2015 · 838 citations · Full text

Life Sciences, Cancer Biology, Immunology +14

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Mohamad Hamieh, Anton Dobrin, Annalisa Cabriolu et al. · Nature · 2019 · 656 citations · Full text

Life Sciences, Cancer Biology, Immunology +14

Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling

Scott Wilkie, May CI van Schalkwyk, Steve Hobbs et al. · Journal of Clinical Immunology · 2012 · 484 citations

Medicine, Cancer Biology, Oncology +12