De Novo <scp><i>PACSIN1</i></scp> Gene Variant Found in Childhood Lupus and a Role for <scp>PACSIN1</scp>/<scp>TRAF4</scp> Complex in Toll‐like Receptor 7 Activation

Abstract

PACSIN1 Q59K increases IFNβ activity through the impairment of TRAF4-mediated inhibition of TLR-7 signaling, possibly contributing to SLE risk.