Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Scott A. Jenks, Kevin S. Cashman, Esther Zumaquero, +20

Immunity

InflammationToll-like ReceptorsMolecular ImmunologyAutoimmune DiseaseSystemic Lupus Erythematosus +8

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

Matthew C. Woodruff, Richard P. Ramonell, Doan C. Nguyen, +30

Nature Immunology

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

Christopher M. Tipton, Christopher Fucile, Jaime Darce, +13

Nature Immunology

ImmunogeneticsCellular OriginAutoimmune DiseaseSystemic Lupus ErythematosusAutoantibody Production +7

The Kinetic Stability of MHC Class II:Peptide Complexes Is a Key Parameter that Dictates Immunodominance

Christopher A. Lazarski, Francisco A. Chaves, Scott A. Jenks, +4

Immunity

Autoimmune DiseaseBiochemistryNatural SciencesPeptide LibraryHla Immunogenetics +11

Epigenetic programming underpins B cell dysfunction in human SLE

Christopher D. Scharer, Emily L. Blalock, Mi Tian, +12

Nature Immunology

ChromatinEpigenetic ChangeGeneticsEpigenomicsSystems Biology +3

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

Esther Zumaquero, Sara L. Stone, Christopher D. Scharer, +18

eLife

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

Matthew C. Woodruff, Richard P. Ramonell, Natalie S. Haddad, +27

Nature

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

Matthew C. Woodruff, Kevin S. Bonham, Fabliha A. Anam, +22

Nature Communications

InflammationPasc CategorizationLong CovidAutoimmune DiseaseImmunology +11

Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus

Christopher T. Richardson, Asiya Seema Chida, Diana G. Adlowitz, +11

The Journal of Immunology

ImmunologyImmunotherapyImmunogeneticsAutoantigensAutoantibodies +15

Relaxed peripheral tolerance drives broad <i>de novo</i> autoreactivity in severe COVID-19

Matthew C. Woodruff, Richard P. Ramonell, Ankur Singh Saini, +13